Serveur d'exploration sur la COVID en France

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Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.

Identifieur interne : 000D57 ( Main/Exploration ); précédent : 000D56; suivant : 000D58

Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.

Auteurs : Nikolaos G. Papadopoulos [Grèce] ; Adnan Custovic [Royaume-Uni] ; Antoine Deschildre [France] ; Alexander G. Mathioudakis [Royaume-Uni] ; Wanda Phipatanakul ; Gary Wong [Hong Kong] ; Paraskevi Xepapadaki [Grèce] ; Ioana Agache [Roumanie] ; Leonard Bacharier ; Matteo Bonini [Royaume-Uni] ; Jose A. Castro-Rodriguez [Chili] ; Zhimin Chen [République populaire de Chine] ; Timothy Craig ; Francine M. Ducharme [Canada] ; Zeinab Awad El-Sayed [Égypte] ; Wojciech Feleszko [Pologne] ; Alessandro Fiocchi [Italie] ; Luis Garcia-Marcos [Espagne] ; James E. Gern ; Anne Goh ; René Maximiliano G Mez [Argentine] ; Eckard H. Hamelmann [Allemagne] ; Gunilla Hedlin [Suède] ; Elham M. Hossny [Égypte] ; Tuomas Jartti [Finlande] ; Omer Kalayci [Turquie] ; Alan Kaplan [Canada] ; Jon Konradsen [Suède] ; Piotr Kuna [Pologne] ; Susanne Lau [Allemagne] ; Peter Le Souef [Australie] ; Robert F. Lemanske ; Mika J. M Kel [Finlande] ; Mário Morais-Almeida [Portugal] ; Clare Murray [Royaume-Uni] ; Karthik Nagaraju [Inde] ; Leyla Namazova-Baranova [Russie] ; Antonio Nieto Garcia [Espagne] ; Osman M. Yusuf [Royaume-Uni] ; Paulo M C. Pitrez [Brésil] ; Petr Pohunek [République tchèque] ; Cesar Fireth Pozo Beltrán [Mexique] ; Graham C. Roberts [Royaume-Uni] ; Arunas Valiulis [Lituanie] ; Heather J. Zar [Afrique du Sud]

Source :

RBID : pubmed:32561497

Descripteurs français

English descriptors

Abstract

BACKGROUND

It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.

OBJECTIVE

To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.

METHODS

An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.

RESULTS

Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.

CONCLUSIONS

Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.


DOI: 10.1016/j.jaip.2020.06.001
PubMed: 32561497
PubMed Central: PMC7297686


Affiliations:


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<name sortKey="Craig, Timothy" sort="Craig, Timothy" uniqKey="Craig T" first="Timothy" last="Craig">Timothy Craig</name>
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<name sortKey="Ducharme, Francine M" sort="Ducharme, Francine M" uniqKey="Ducharme F" first="Francine M" last="Ducharme">Francine M. Ducharme</name>
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<name sortKey="El Sayed, Zeinab Awad" sort="El Sayed, Zeinab Awad" uniqKey="El Sayed Z" first="Zeinab Awad" last="El-Sayed">Zeinab Awad El-Sayed</name>
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<country xml:lang="fr">Espagne</country>
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<name sortKey="Gern, James E" sort="Gern, James E" uniqKey="Gern J" first="James E" last="Gern">James E. Gern</name>
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<name sortKey="Goh, Anne" sort="Goh, Anne" uniqKey="Goh A" first="Anne" last="Goh">Anne Goh</name>
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<nlm:affiliation>Department of Internal Medicine, Rush Medical College, Chicago, Ill.</nlm:affiliation>
<wicri:noCountry code="subField">Ill</wicri:noCountry>
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<name sortKey="G Mez, Rene Maximiliano" sort="G Mez, Rene Maximiliano" uniqKey="G Mez R" first="René Maximiliano" last="G Mez">René Maximiliano G Mez</name>
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<name sortKey="Hamelmann, Eckard H" sort="Hamelmann, Eckard H" uniqKey="Hamelmann E" first="Eckard H" last="Hamelmann">Eckard H. Hamelmann</name>
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<nlm:affiliation>Children's Center Bethel, EvKB, University Bielefeld, Bielefeld, Germany.</nlm:affiliation>
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<name sortKey="Hedlin, Gunilla" sort="Hedlin, Gunilla" uniqKey="Hedlin G" first="Gunilla" last="Hedlin">Gunilla Hedlin</name>
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<name sortKey="Hossny, Elham M" sort="Hossny, Elham M" uniqKey="Hossny E" first="Elham M" last="Hossny">Elham M. Hossny</name>
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<nlm:affiliation>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo</wicri:regionArea>
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<name sortKey="Jartti, Tuomas" sort="Jartti, Tuomas" uniqKey="Jartti T" first="Tuomas" last="Jartti">Tuomas Jartti</name>
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<name sortKey="Kaplan, Alan" sort="Kaplan, Alan" uniqKey="Kaplan A" first="Alan" last="Kaplan">Alan Kaplan</name>
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<nlm:affiliation>Family Physician Airways Group of Canada, Edmonton, AB, Canada.</nlm:affiliation>
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<name sortKey="Konradsen, Jon" sort="Konradsen, Jon" uniqKey="Konradsen J" first="Jon" last="Konradsen">Jon Konradsen</name>
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<nlm:affiliation>Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Kuna, Piotr" sort="Kuna, Piotr" uniqKey="Kuna P" first="Piotr" last="Kuna">Piotr Kuna</name>
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<name sortKey="Lau, Susanne" sort="Lau, Susanne" uniqKey="Lau S" first="Susanne" last="Lau">Susanne Lau</name>
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<nlm:affiliation>Charité Universitätsmedizin Berlin, Pediatric Pulmonology, Immunology and Intensive Care Medicine, Berlin, Germany.</nlm:affiliation>
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<name sortKey="Le Souef, Peter" sort="Le Souef, Peter" uniqKey="Le Souef P" first="Peter" last="Le Souef">Peter Le Souef</name>
<affiliation wicri:level="1">
<nlm:affiliation>School of Paediatrics & Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, WA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<name sortKey="Lemanske, Robert F" sort="Lemanske, Robert F" uniqKey="Lemanske R" first="Robert F" last="Lemanske">Robert F. Lemanske</name>
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<nlm:affiliation>Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.</nlm:affiliation>
<wicri:noCountry code="subField">Wis</wicri:noCountry>
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<author>
<name sortKey="M Kel, Mika J" sort="M Kel, Mika J" uniqKey="M Kel M" first="Mika J" last="M Kel">Mika J. M Kel</name>
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<nlm:affiliation>Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Allergy, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
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<author>
<name sortKey="Morais Almeida, Mario" sort="Morais Almeida, Mario" uniqKey="Morais Almeida M" first="Mário" last="Morais-Almeida">Mário Morais-Almeida</name>
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<nlm:affiliation>Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.</nlm:affiliation>
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<name sortKey="Murray, Clare" sort="Murray, Clare" uniqKey="Murray C" first="Clare" last="Murray">Clare Murray</name>
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<nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester</wicri:regionArea>
<placeName>
<settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author>
<name sortKey="Nagaraju, Karthik" sort="Nagaraju, Karthik" uniqKey="Nagaraju K" first="Karthik" last="Nagaraju">Karthik Nagaraju</name>
<affiliation wicri:level="1">
<nlm:affiliation>VN Allergy & Asthma Research Centre, Chennai, Tamilnadu, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>VN Allergy & Asthma Research Centre, Chennai, Tamilnadu</wicri:regionArea>
<wicri:noRegion>Tamilnadu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Namazova Baranova, Leyla" sort="Namazova Baranova, Leyla" uniqKey="Namazova Baranova L" first="Leyla" last="Namazova-Baranova">Leyla Namazova-Baranova</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Department, Pirogov Russian National Research Medical University, the Ministry of Health, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Pediatric Department, Pirogov Russian National Research Medical University, the Ministry of Health, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Garcia, Antonio Nieto" sort="Garcia, Antonio Nieto" uniqKey="Garcia A" first="Antonio Nieto" last="Garcia">Antonio Nieto Garcia</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Pulmonology & Allergy Unit, Children's Hospital la Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pediatric Pulmonology & Allergy Unit, Children's Hospital la Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Yusuf, Osman M" sort="Yusuf, Osman M" uniqKey="Yusuf O" first="Osman M" last="Yusuf">Osman M. Yusuf</name>
<affiliation wicri:level="4">
<nlm:affiliation>Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Pitrez, Paulo M C" sort="Pitrez, Paulo M C" uniqKey="Pitrez P" first="Paulo M C" last="Pitrez">Paulo M C. Pitrez</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Pulmonology Division, Hospital Moinhos de Vento, Porto Alegre, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Pulmonology Division, Hospital Moinhos de Vento, Porto Alegre</wicri:regionArea>
<placeName>
<settlement type="city">Porto Alegre</settlement>
<region type="state">Rio Grande do Sul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pohunek, Petr" sort="Pohunek, Petr" uniqKey="Pohunek P" first="Petr" last="Pohunek">Petr Pohunek</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Pulmonology, Pediatric Department, 2nd Faculty of Medicine, Charles University, Prague, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Pediatric Pulmonology, Pediatric Department, 2nd Faculty of Medicine, Charles University, Prague, University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pozo Beltran, Cesar Fireth" sort="Pozo Beltran, Cesar Fireth" uniqKey="Pozo Beltran C" first="Cesar Fireth" last="Pozo Beltrán">Cesar Fireth Pozo Beltrán</name>
<affiliation wicri:level="1">
<nlm:affiliation>Teaching and Research Department and Paediatric Allergy Department, Hospital with Specialties Juan María de Salvatierra, La Paz, Baja California Sur México, La Paz, Mexico; Allergy & Immunology Department, Hospital Infantil de Medico Federico Gomez, Mexico City, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Teaching and Research Department and Paediatric Allergy Department, Hospital with Specialties Juan María de Salvatierra, La Paz, Baja California Sur México, La Paz, Mexico; Allergy & Immunology Department, Hospital Infantil de Medico Federico Gomez, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Roberts, Graham C" sort="Roberts, Graham C" uniqKey="Roberts G" first="Graham C" last="Roberts">Graham C. Roberts</name>
<affiliation wicri:level="1">
<nlm:affiliation>Paediatric Allergy and Respiratory Medicine within Medicine at the University of Southampton, Southampton, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Paediatric Allergy and Respiratory Medicine within Medicine at the University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Valiulis, Arunas" sort="Valiulis, Arunas" uniqKey="Valiulis A" first="Arunas" last="Valiulis">Arunas Valiulis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Clinic of Children's Diseases, Institute of Clinical Medicine, Medical Faculty of Vilnius University, Vilnius, Lithuania.</nlm:affiliation>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Clinic of Children's Diseases, Institute of Clinical Medicine, Medical Faculty of Vilnius University, Vilnius</wicri:regionArea>
<wicri:noRegion>Vilnius</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zar, Heather J" sort="Zar, Heather J" uniqKey="Zar H" first="Heather J" last="Zar">Heather J. Zar</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics & Child Health, MRC Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Department of Pediatrics & Child Health, MRC Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
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<idno type="RBID">pubmed:32561497</idno>
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<title xml:lang="en">Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.</title>
<author>
<name sortKey="Papadopoulos, Nikolaos G" sort="Papadopoulos, Nikolaos G" uniqKey="Papadopoulos N" first="Nikolaos G" last="Papadopoulos">Nikolaos G. Papadopoulos</name>
<affiliation wicri:level="4">
<nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: ngpallergy@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens</wicri:regionArea>
<placeName>
<settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author>
<name sortKey="Custovic, Adnan" sort="Custovic, Adnan" uniqKey="Custovic A" first="Adnan" last="Custovic">Adnan Custovic</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Paediatrics, Imperial College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Paediatrics, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Deschildre, Antoine" sort="Deschildre, Antoine" uniqKey="Deschildre A" first="Antoine" last="Deschildre">Antoine Deschildre</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mathioudakis, Alexander G" sort="Mathioudakis, Alexander G" uniqKey="Mathioudakis A" first="Alexander G" last="Mathioudakis">Alexander G. Mathioudakis</name>
<affiliation wicri:level="4">
<nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester</wicri:regionArea>
<placeName>
<settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author>
<name sortKey="Phipatanakul, Wanda" sort="Phipatanakul, Wanda" uniqKey="Phipatanakul W" first="Wanda" last="Phipatanakul">Wanda Phipatanakul</name>
<affiliation>
<nlm:affiliation>Children's Hospital Boston, Pediatric Allergy and Immunology, Boston, Mass.</nlm:affiliation>
<wicri:noCountry code="subField">Mass</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Wong, Gary" sort="Wong, Gary" uniqKey="Wong G" first="Gary" last="Wong">Gary Wong</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin</wicri:regionArea>
<placeName>
<settlement type="city">Sha Tin</settlement>
<region type="Région">Hong Kong</region>
</placeName>
<orgName type="university">Université chinoise de Hong Kong</orgName>
</affiliation>
</author>
<author>
<name sortKey="Xepapadaki, Paraskevi" sort="Xepapadaki, Paraskevi" uniqKey="Xepapadaki P" first="Paraskevi" last="Xepapadaki">Paraskevi Xepapadaki</name>
<affiliation wicri:level="3">
<nlm:affiliation>Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens</wicri:regionArea>
<placeName>
<settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Agache, Ioana" sort="Agache, Ioana" uniqKey="Agache I" first="Ioana" last="Agache">Ioana Agache</name>
<affiliation wicri:level="1">
<nlm:affiliation>Allergy & Clinical Immunology, Transylvania University, Brasov, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Allergy & Clinical Immunology, Transylvania University, Brasov</wicri:regionArea>
<wicri:noRegion>Brasov</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bacharier, Leonard" sort="Bacharier, Leonard" uniqKey="Bacharier L" first="Leonard" last="Bacharier">Leonard Bacharier</name>
<affiliation>
<nlm:affiliation>Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St Louis, Mo.</nlm:affiliation>
<wicri:noCountry code="subField">Mo</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Bonini, Matteo" sort="Bonini, Matteo" uniqKey="Bonini M" first="Matteo" last="Bonini">Matteo Bonini</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Cardiovascular and Thoracic Sciences, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy; National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular and Thoracic Sciences, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy; National Heart and Lung Institute (NHLI), Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Castro Rodriguez, Jose A" sort="Castro Rodriguez, Jose A" uniqKey="Castro Rodriguez J" first="Jose A" last="Castro-Rodriguez">Jose A. Castro-Rodriguez</name>
<affiliation wicri:level="1">
<nlm:affiliation>Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.</nlm:affiliation>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chen, Zhimin" sort="Chen, Zhimin" uniqKey="Chen Z" first="Zhimin" last="Chen">Zhimin Chen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pulmonology Department, Children's Hospital Zhejiang University School of Medicine, Zhejiang, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Pulmonology Department, Children's Hospital Zhejiang University School of Medicine, Zhejiang</wicri:regionArea>
<wicri:noRegion>Zhejiang</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Craig, Timothy" sort="Craig, Timothy" uniqKey="Craig T" first="Timothy" last="Craig">Timothy Craig</name>
<affiliation>
<nlm:affiliation>Department of Allergy and Immunology, Penn State University, State College, Pa.</nlm:affiliation>
<wicri:noCountry code="subField">Pa</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Ducharme, Francine M" sort="Ducharme, Francine M" uniqKey="Ducharme F" first="Francine M" last="Ducharme">Francine M. Ducharme</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics, University of Montréal, Department of Social and Preventive Medicine, University of Montréal, Montréal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pediatrics, University of Montréal, Department of Social and Preventive Medicine, University of Montréal, Montréal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="El Sayed, Zeinab Awad" sort="El Sayed, Zeinab Awad" uniqKey="El Sayed Z" first="Zeinab Awad" last="El-Sayed">Zeinab Awad El-Sayed</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Feleszko, Wojciech" sort="Feleszko, Wojciech" uniqKey="Feleszko W" first="Wojciech" last="Feleszko">Wojciech Feleszko</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatric Respiratory Diseases and Allergy, The Medical University of Warsaw, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Pediatric Respiratory Diseases and Allergy, The Medical University of Warsaw, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fiocchi, Alessandro" sort="Fiocchi, Alessandro" uniqKey="Fiocchi A" first="Alessandro" last="Fiocchi">Alessandro Fiocchi</name>
<affiliation wicri:level="3">
<nlm:affiliation>Allergy Department, Bambino Gesù Children's Hospital, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Allergy Department, Bambino Gesù Children's Hospital, Rome</wicri:regionArea>
<placeName>
<settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Garcia Marcos, Luis" sort="Garcia Marcos, Luis" uniqKey="Garcia Marcos L" first="Luis" last="Garcia-Marcos">Luis Garcia-Marcos</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Respiratory and Allergy Units, "Virgen de la Arrixaca" Children's University Clinical Hospital, University of Murcia, Murcia, Spain; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, & Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Murcia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pediatric Respiratory and Allergy Units, "Virgen de la Arrixaca" Children's University Clinical Hospital, University of Murcia, Murcia, Spain; Institute for Biomedical Research of Murcia, IMIB-Arrixaca, & Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Murcia</wicri:regionArea>
<wicri:noRegion>Murcia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gern, James E" sort="Gern, James E" uniqKey="Gern J" first="James E" last="Gern">James E. Gern</name>
<affiliation>
<nlm:affiliation>Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.</nlm:affiliation>
<wicri:noCountry code="subField">Wis</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Goh, Anne" sort="Goh, Anne" uniqKey="Goh A" first="Anne" last="Goh">Anne Goh</name>
<affiliation>
<nlm:affiliation>Department of Internal Medicine, Rush Medical College, Chicago, Ill.</nlm:affiliation>
<wicri:noCountry code="subField">Ill</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="G Mez, Rene Maximiliano" sort="G Mez, Rene Maximiliano" uniqKey="G Mez R" first="René Maximiliano" last="G Mez">René Maximiliano G Mez</name>
<affiliation wicri:level="1">
<nlm:affiliation>Research & Education, Ayre Foundation, Salta, Argentina; Allergy & Asthma Department, Alas Medical Institute, Salta, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Research & Education, Ayre Foundation, Salta, Argentina; Allergy & Asthma Department, Alas Medical Institute, Salta</wicri:regionArea>
<wicri:noRegion>Salta</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hamelmann, Eckard H" sort="Hamelmann, Eckard H" uniqKey="Hamelmann E" first="Eckard H" last="Hamelmann">Eckard H. Hamelmann</name>
<affiliation wicri:level="1">
<nlm:affiliation>Children's Center Bethel, EvKB, University Bielefeld, Bielefeld, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Children's Center Bethel, EvKB, University Bielefeld, Bielefeld</wicri:regionArea>
<wicri:noRegion>Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
<wicri:noRegion>Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hedlin, Gunilla" sort="Hedlin, Gunilla" uniqKey="Hedlin G" first="Gunilla" last="Hedlin">Gunilla Hedlin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Paediatric Allergy, Centre for Allergy Research, Karolinska Institutet, Solna, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Paediatric Allergy, Centre for Allergy Research, Karolinska Institutet, Solna</wicri:regionArea>
<wicri:noRegion>Solna</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hossny, Elham M" sort="Hossny, Elham M" uniqKey="Hossny E" first="Elham M" last="Hossny">Elham M. Hossny</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo</wicri:regionArea>
<wicri:noRegion>Cairo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jartti, Tuomas" sort="Jartti, Tuomas" uniqKey="Jartti T" first="Tuomas" last="Jartti">Tuomas Jartti</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku</wicri:regionArea>
<placeName>
<settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kalayci, Omer" sort="Kalayci, Omer" uniqKey="Kalayci O" first="Omer" last="Kalayci">Omer Kalayci</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara</wicri:regionArea>
<wicri:noRegion>Ankara</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kaplan, Alan" sort="Kaplan, Alan" uniqKey="Kaplan A" first="Alan" last="Kaplan">Alan Kaplan</name>
<affiliation wicri:level="1">
<nlm:affiliation>Family Physician Airways Group of Canada, Edmonton, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Family Physician Airways Group of Canada, Edmonton, AB</wicri:regionArea>
<wicri:noRegion>AB</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Konradsen, Jon" sort="Konradsen, Jon" uniqKey="Konradsen J" first="Jon" last="Konradsen">Jon Konradsen</name>
<affiliation wicri:level="3">
<nlm:affiliation>Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kuna, Piotr" sort="Kuna, Piotr" uniqKey="Kuna P" first="Piotr" last="Kuna">Piotr Kuna</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lau, Susanne" sort="Lau, Susanne" uniqKey="Lau S" first="Susanne" last="Lau">Susanne Lau</name>
<affiliation wicri:level="3">
<nlm:affiliation>Charité Universitätsmedizin Berlin, Pediatric Pulmonology, Immunology and Intensive Care Medicine, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Charité Universitätsmedizin Berlin, Pediatric Pulmonology, Immunology and Intensive Care Medicine, Berlin</wicri:regionArea>
<placeName>
<region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Le Souef, Peter" sort="Le Souef, Peter" uniqKey="Le Souef P" first="Peter" last="Le Souef">Peter Le Souef</name>
<affiliation wicri:level="1">
<nlm:affiliation>School of Paediatrics & Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, WA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Paediatrics & Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lemanske, Robert F" sort="Lemanske, Robert F" uniqKey="Lemanske R" first="Robert F" last="Lemanske">Robert F. Lemanske</name>
<affiliation>
<nlm:affiliation>Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.</nlm:affiliation>
<wicri:noCountry code="subField">Wis</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="M Kel, Mika J" sort="M Kel, Mika J" uniqKey="M Kel M" first="Mika J" last="M Kel">Mika J. M Kel</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Allergy, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Morais Almeida, Mario" sort="Morais Almeida, Mario" uniqKey="Morais Almeida M" first="Mário" last="Morais-Almeida">Mário Morais-Almeida</name>
<affiliation wicri:level="1">
<nlm:affiliation>Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Allergy Center, CUF Descobertas Hospital, Lisbon</wicri:regionArea>
<wicri:noRegion>Lisbon</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Murray, Clare" sort="Murray, Clare" uniqKey="Murray C" first="Clare" last="Murray">Clare Murray</name>
<affiliation wicri:level="4">
<nlm:affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester</wicri:regionArea>
<placeName>
<settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author>
<name sortKey="Nagaraju, Karthik" sort="Nagaraju, Karthik" uniqKey="Nagaraju K" first="Karthik" last="Nagaraju">Karthik Nagaraju</name>
<affiliation wicri:level="1">
<nlm:affiliation>VN Allergy & Asthma Research Centre, Chennai, Tamilnadu, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>VN Allergy & Asthma Research Centre, Chennai, Tamilnadu</wicri:regionArea>
<wicri:noRegion>Tamilnadu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Namazova Baranova, Leyla" sort="Namazova Baranova, Leyla" uniqKey="Namazova Baranova L" first="Leyla" last="Namazova-Baranova">Leyla Namazova-Baranova</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Department, Pirogov Russian National Research Medical University, the Ministry of Health, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Pediatric Department, Pirogov Russian National Research Medical University, the Ministry of Health, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Garcia, Antonio Nieto" sort="Garcia, Antonio Nieto" uniqKey="Garcia A" first="Antonio Nieto" last="Garcia">Antonio Nieto Garcia</name>
<affiliation wicri:level="1">
<nlm:affiliation>Pediatric Pulmonology & Allergy Unit, Children's Hospital la Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Pediatric Pulmonology & Allergy Unit, Children's Hospital la Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Yusuf, Osman M" sort="Yusuf, Osman M" uniqKey="Yusuf O" first="Osman M" last="Yusuf">Osman M. Yusuf</name>
<affiliation wicri:level="4">
<nlm:affiliation>Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Pitrez, Paulo M C" sort="Pitrez, Paulo M C" uniqKey="Pitrez P" first="Paulo M C" last="Pitrez">Paulo M C. Pitrez</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Pulmonology Division, Hospital Moinhos de Vento, Porto Alegre, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Pulmonology Division, Hospital Moinhos de Vento, Porto Alegre</wicri:regionArea>
<placeName>
<settlement type="city">Porto Alegre</settlement>
<region type="state">Rio Grande do Sul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pohunek, Petr" sort="Pohunek, Petr" uniqKey="Pohunek P" first="Petr" last="Pohunek">Petr Pohunek</name>
<affiliation wicri:level="3">
<nlm:affiliation>Pediatric Pulmonology, Pediatric Department, 2nd Faculty of Medicine, Charles University, Prague, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Pediatric Pulmonology, Pediatric Department, 2nd Faculty of Medicine, Charles University, Prague, University Hospital Motol, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pozo Beltran, Cesar Fireth" sort="Pozo Beltran, Cesar Fireth" uniqKey="Pozo Beltran C" first="Cesar Fireth" last="Pozo Beltrán">Cesar Fireth Pozo Beltrán</name>
<affiliation wicri:level="1">
<nlm:affiliation>Teaching and Research Department and Paediatric Allergy Department, Hospital with Specialties Juan María de Salvatierra, La Paz, Baja California Sur México, La Paz, Mexico; Allergy & Immunology Department, Hospital Infantil de Medico Federico Gomez, Mexico City, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Teaching and Research Department and Paediatric Allergy Department, Hospital with Specialties Juan María de Salvatierra, La Paz, Baja California Sur México, La Paz, Mexico; Allergy & Immunology Department, Hospital Infantil de Medico Federico Gomez, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Roberts, Graham C" sort="Roberts, Graham C" uniqKey="Roberts G" first="Graham C" last="Roberts">Graham C. Roberts</name>
<affiliation wicri:level="1">
<nlm:affiliation>Paediatric Allergy and Respiratory Medicine within Medicine at the University of Southampton, Southampton, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Paediatric Allergy and Respiratory Medicine within Medicine at the University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Valiulis, Arunas" sort="Valiulis, Arunas" uniqKey="Valiulis A" first="Arunas" last="Valiulis">Arunas Valiulis</name>
<affiliation wicri:level="1">
<nlm:affiliation>Clinic of Children's Diseases, Institute of Clinical Medicine, Medical Faculty of Vilnius University, Vilnius, Lithuania.</nlm:affiliation>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Clinic of Children's Diseases, Institute of Clinical Medicine, Medical Faculty of Vilnius University, Vilnius</wicri:regionArea>
<wicri:noRegion>Vilnius</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zar, Heather J" sort="Zar, Heather J" uniqKey="Zar H" first="Heather J" last="Zar">Heather J. Zar</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics & Child Health, MRC Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Department of Pediatrics & Child Health, MRC Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The journal of allergy and clinical immunology. In practice</title>
<idno type="eISSN">2213-2201</idno>
<imprint>
<date when="2020" type="published">2020</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Appointments and Schedules (MeSH)</term>
<term>Asthma (epidemiology)</term>
<term>Asthma (physiopathology)</term>
<term>Asthma (therapy)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Child (MeSH)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Global Health (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Medication Adherence (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Telemedicine (organization & administration)</term>
<term>Telemedicine (statistics & numerical data)</term>
<term>Time Factors (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adhésion au traitement médicamenteux (MeSH)</term>
<term>Asthme (physiopathologie)</term>
<term>Asthme (thérapie)</term>
<term>Asthme (épidémiologie)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Enfant (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Rendez-vous et plannings (MeSH)</term>
<term>Santé mondiale (MeSH)</term>
<term>Télémédecine (organisation et administration)</term>
<term>Télémédecine (statistiques et données numériques)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Asthma</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr">
<term>Télémédecine</term>
</keywords>
<keywords scheme="MESH" qualifier="organization & administration" xml:lang="en">
<term>Telemedicine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Asthme</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Asthma</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Telemedicine</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr">
<term>Télémédecine</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Asthma</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr">
<term>Asthme</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Asthme</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Appointments and Schedules</term>
<term>Betacoronavirus</term>
<term>Child</term>
<term>Global Health</term>
<term>Humans</term>
<term>Medication Adherence</term>
<term>Pandemics</term>
<term>Severity of Illness Index</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adhésion au traitement médicamenteux</term>
<term>Betacoronavirus</term>
<term>Enfant</term>
<term>Facteurs temps</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Pandémies</term>
<term>Rendez-vous et plannings</term>
<term>Santé mondiale</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVE</b>
</p>
<p>To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">32561497</PMID>
<DateCompleted>
<Year>2020</Year>
<Month>09</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">2213-2201</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>8</Volume>
<Issue>8</Issue>
<PubDate>
<Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>The journal of allergy and clinical immunology. In practice</Title>
<ISOAbbreviation>J Allergy Clin Immunol Pract</ISOAbbreviation>
</Journal>
<ArticleTitle>Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden.</ArticleTitle>
<Pagination>
<MedlinePgn>2592-2599.e3</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S2213-2198(20)30599-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaip.2020.06.001</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND">It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic.</AbstractText>
<AbstractText Label="OBJECTIVE">To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients.</AbstractText>
<AbstractText Label="METHODS">An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma.</AbstractText>
<AbstractText Label="RESULTS">Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts.</AbstractText>
<AbstractText Label="CONCLUSIONS">Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.</AbstractText>
<CopyrightInformation>Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Papadopoulos</LastName>
<ForeName>Nikolaos G</ForeName>
<Initials>NG</Initials>
<AffiliationInfo>
<Affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: ngpallergy@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Custovic</LastName>
<ForeName>Adnan</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Paediatrics, Imperial College London, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Deschildre</LastName>
<ForeName>Antoine</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mathioudakis</LastName>
<ForeName>Alexander G</ForeName>
<Initials>AG</Initials>
<AffiliationInfo>
<Affiliation>Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Phipatanakul</LastName>
<ForeName>Wanda</ForeName>
<Initials>W</Initials>
<AffiliationInfo>
<Affiliation>Children's Hospital Boston, Pediatric Allergy and Immunology, Boston, Mass.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wong</LastName>
<ForeName>Gary</ForeName>
<Initials>G</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Xepapadaki</LastName>
<ForeName>Paraskevi</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Agache</LastName>
<ForeName>Ioana</ForeName>
<Initials>I</Initials>
<AffiliationInfo>
<Affiliation>Allergy & Clinical Immunology, Transylvania University, Brasov, Romania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bacharier</LastName>
<ForeName>Leonard</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University, St Louis, Mo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bonini</LastName>
<ForeName>Matteo</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Cardiovascular and Thoracic Sciences, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy; National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Castro-Rodriguez</LastName>
<ForeName>Jose A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo>
<Affiliation>Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chen</LastName>
<ForeName>Zhimin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo>
<Affiliation>Pulmonology Department, Children's Hospital Zhejiang University School of Medicine, Zhejiang, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Craig</LastName>
<ForeName>Timothy</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Allergy and Immunology, Penn State University, State College, Pa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ducharme</LastName>
<ForeName>Francine M</ForeName>
<Initials>FM</Initials>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, University of Montréal, Department of Social and Preventive Medicine, University of Montréal, Montréal, QC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>El-Sayed</LastName>
<ForeName>Zeinab Awad</ForeName>
<Initials>ZA</Initials>
<AffiliationInfo>
<Affiliation>Pediatric Allergy and Immunology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Feleszko</LastName>
<ForeName>Wojciech</ForeName>
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